高血压病患者动脉硬化指数增高的相关因素分析

目的观察动脉硬化指数(ASI)增高的高血压病患者,探讨其临床一般情况、血液生化指标等特点,分析临床意义。方法随机检测156例高血压病患者的动脉硬化指数、血压、脉压,并检测患者的血尿酸、血糖、血脂、肌酐、尿素氮等血液生化指标。按照患者的ASI分为两组。ASI正常组:127例,ASI值在0~70之间;ASI增高组:29例,ASI值为71或以上。结果(1)ASI增高组患者的年龄、病史、收缩压和脉压显著高于ASI正常组,其舒张压显著低于ASI正常组(均P<0.01)。(2)ASI增高组患者的血尿酸(P<0.01),尿素氮(P<0.05)水平也显著增高。结论年龄大、病史时间长、收缩压升高、舒张压降低、脉压增大、血尿酸和尿素氮水平升高均可能与ASI异常增高相关联。

The Clinical characteristic of essential hypertensive patients with high arterial stiffness index

Objective To investigate the clinical characteristic of essential hypertensive patients with high arterial stiffness index (ASI).Methods One hundred and fifty six essential hypertensive patients were recruited randomly in the outpatient department of high blood pressure of the General Hospital of PLA.The patients were divided into two groups according to their ASI values.They were normal ASI group(n=127) with the ASI values ranging from zero to seventy and high ASI value group (n=29) with the ASI values higher than seventy.The demographic parameters,arterial stiffness index and blood biochemical parameters were measured and compared between the two groups.Results The patients with abnormal high ASI values possessed older age,longer hypertensive history,higher systolic blood pressure and pulse pressure,but lower diastolic blood pressure (all P<0.01) comparing with the patients with normal ASI values.In the high ASI value group,the levels of both blood uric acid (P<0.01) and blood urea nitrogen (P<0.05) were higher than the normal ASI value group.Conclusion Old age,long hypertensive history,high systolic blood pressure and pulse pressure,low diastolic blood pressure,high levels of blood uric acid and blood urea nitrogen may be associated with essential hypertensive patients with high ASI values.