| 别嘌醇缓释片的制备及释药机理的初步探讨 |
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| 引用本文： | 王珣,孙佩男,栾琳,孟晋,李颖,潘卫三.别嘌醇缓释片的制备及释药机理的初步探讨[J].沈阳药科大学学报,2007,24(3):138-141. |
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| 作者姓名： | 王珣 孙佩男 栾琳 孟晋 李颖 潘卫三 |
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| 作者单位： | 1. 沈阳药科大学,药学院,辽宁,沈阳,110016
2. 复旦大学,附属华山医院,上海,200040 |
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| 摘 要： | 目的制备别嘌醇缓释片并探讨其释药机理。方法采用正交试验法进行处方优化,用数学模型拟合释放曲线。结果羟丙基甲基纤维素(HPMC)和乳糖的用量对释药有显著性影响,别嘌醇缓释骨架片的体外释药行为符合零级释放模型。结论制备出体外释放度符合要求的别嘌醇缓释片。
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| 关 键 词： | 别嘌醇 羟丙基甲基纤维素(HPMC) 缓释片 释药机理 |
| 文章编号： | 1006-2858（2007）03-0138-04 |
| 收稿时间： | 2006-02-08 |
| 修稿时间： | 2006年2月8日 |
Preparation and the release mechanism of allopurinol sustained-release tablets |
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| WANG Xun,SUN Pei-nan,LUAN Lin,MENG Jin,LI Ying,PAN Wei-san.Preparation and the release mechanism of allopurinol sustained-release tablets[J].Journal of Shenyang Pharmaceutical University,2007,24(3):138-141. |
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| Authors: | WANG Xun SUN Pei-nan LUAN Lin MENG Jin LI Ying PAN Wei-san |
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| Abstract: | Objective To prepare the allopurinol sustained-release tablets and study the release mechanism. Methods Orthogonal experiment was carried out to optimize the formulation. Several mathematic models were used to imitated the drug release. Results The amount of HPMC and lactose had significant effects on the release of allopurinol. The release behavior of the tablets followed the zero order equation. Conclusions The allopurinol sustained-release formulation which meets the release requirement in vitro is prepared. |
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| Keywords: | allopurinol HPMC sustained-release tablets release mechanism |
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