乌丹醒肝颗粒对大鼠急性酒精性肝损伤的影响

目的研究乌丹醒肝颗粒对大鼠急性酒精性肝损伤的影响.方法将大鼠灌胃给予56°红星二锅头,制备急性酒精性肝损伤大鼠模型;末次给药后测定血清ALT、AST、MDA、GSH-PX及肝匀浆中SOD、MDA、GSH-PX等各项指标含量计算肝系数.结果乌丹醒肝颗粒中剂量对造模大鼠血清ALT升高有显著降低作用,对造模大鼠血清GSH-PX活性降低有显著的升高作用;乌丹醒肝颗粒对造模大鼠血清AST升高有降低作用;乌丹醒肝颗粒大剂量对造模大鼠肝组织MDA水平升高有显著且呈剂量依赖性的降低作用;乌丹醒肝颗粒大、中、小剂量可以显著提高造模大鼠肝组织GSH-PX和SOD活性.结论乌丹醒肝颗粒对大鼠急性酒精性肝损伤具有较好的治疗作用,为其临床用药提供了药效学基础.

Effect of Wudanxinggan Granule on rat acute alcoholic liver injury

OBJECTIVE To study the effect of Wudanxinggan therapying acute alcoholic liver injury rat.METHODS The rat model of acute alcoholic liver injury was duplicated by filling the stomach with 56° distilled spirit and was given medicine in the same time.After the last time determine the ALT,AST,MDA,GSH-PX in rats' blood serum and SOD,MDA,GSH-PX in liver homogenate.RESULTS Compared with that of model group,it was suggested that the increase of AST activity in rats' serum was decreased evidently in the middle dose group of Wudanxinggan Granule,and it can also increase the decrease of GSH-PX activity in the rats' serum;The Wudanxinggan Granule can decrease the AST activity in the rats' serum;the increase of MDA level in the rats' liver tissue were all decreased remarkably in the high dose group;the GSH-PX and SOD activity of the rats' liver tissue were all increased remarkably in the high,middle and lower dose group.CONCLUSION Wudanxinggan Granule could prevent and treat rat acute alcoholic liver injury palpably.It made a good base of the drug's effect to the study in clinic.