鼻息肉中血管内皮生长因子和碱性成纤维细胞生长因子的表达

目的探讨血管内皮生长因子 (vascular endothelial growth factor,VEGF)和碱性成纤维细胞生长因子 (basic fibroblast growth factor,bFGF)在鼻息肉发病过程中的意义。方法将鼻息肉患者分为A、B2组，A组为Ⅰ型及Ⅱ型1、2期鼻息肉患者，B组为Ⅱ型3期及Ⅲ型鼻息肉患者，采用免疫组化SP法对2组39例鼻息肉患者鼻息肉组织中VEGF、bFGF的表达进行检测。结果正常鼻粘膜中VEGF、bFGF的染色呈阴性，而在A、B组鼻息肉组织中的阳性率分别达到59%、41%和71%、80%，B组中阳性率和阳性细胞数均高于A组；VEGF和bFGF在鼻息肉组织中主要定位于基底膜周围的炎性细胞和上皮细胞以及血管周围和血管壁内皮细胞。结论 VEGF、bFGF通过在鼻息肉组织中的过度表达，促进息肉组织内的血管增殖和炎性细胞聚积，促进鼻息肉的发生发展，可能是鼻息肉病区别于鼻息肉的重要组织学特征之一。

Expressions of vascular endothelial growth factor and basic fibroblast growth factor in nasal polyp and its role

Objective To evaluate the role of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor(bFGF) in the pathophysiology of nasal polyp. Methods Thirty nine patients with nasal polyp were divided into two groups: group A( representing type 1 and type 2 phase 1 2 ) and group B (representing type 2 phase 3 and type 3). The expression of VEGF and bFGF in both groups were studied with immunohistochemical method.Results VEGF and bFGF were not detected in norms. Thedetection rates of VEGF and bFGF were 59%, 41%, and 71%, 80% in group A and group B respectively. The positive rate and the number of positive cells were higher significantly in group B than that in group A. VEGF and bFGF were located mainly in the inflammatory cells and epithelial cells around the basilar membrane and inflammatory cells and endothelial cells around the vessel. Conclusions The overexpression of VEGF and bFGF in nasal polyp may contribute to the growth of vessles , accumulation of inflammatory cells, as a result, to enhance the development of nasal polyposis. This phenomenon maybe an important histological mark distinguishing ordinary polyp from polyposis.