熊果酸磷脂纳米粒的制备与质量评价

目的：对熊果酸纳米粒的制备工艺和含量测定方法进行研究，并对其质量进行评价。方法：用不同的方法制备熊果酸磷脂纳米粒，确定最佳工艺，并对其形态、包封率和pH值等性质进行研究。结果：熊果酸磷脂纳米粒的平均粒径315.0 nm，包封率94.5%，pH值6.35。结论：选择乳化超声法制备熊果酸纳米粒可行，为开发熊果酸新型静脉注射制剂提供了实验依据。

Preparation and Quality Evaluation of Ursolic Acid Phospholipid Nanoparticles

Objective:To study the preparation of ursolic acid phospholipid nanoparticals (UA-PL-NP) and the determination of ursolic acid in UA-PL-NP. Then evaluate its quality. Method:The nanoparticles were prepared by different methods. The morphology of UA-PL-NP, the entrapment efficiency, and the pH were investigated. Results:The nanoparticles were spherical with mean size of 315.0 nm and entrapment efficiency was 94.5%. The pH was 6.35. Conclusion:It is practicable and successful to prepare UA-PL-NP by emulsification-ultrasolication method. It provides experimental evidence to develop a novel ursolic acid preparation for intravenous administration.