The induction of unscheduled DNA synthesis by antihistamines in primary hepatocyte cultures |
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| Authors: | G S Probst S B Neal |
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| Affiliation: | Toxicology Division, Lilly Research Laboratories, Division of Eli Lilly and Company, Greenfield, Indiana 46140 U.S.A. |
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| Abstract: | The autoradiographic identification of chemically-induced, unscheduled DNA synthesis in primary cultures of adult rat hepatocytes is currently being validated as a predictive test for mutagens/carcinogens. Of 8 antihistaminic drugs tested, 2, pyrilamine maleate and tripelennamine HCl, were positive for unscheduled DNA synthesis. Further investigation of the mutagenic/carcinogenic potential of these compounds in alternate test systems is suggested. |
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