A murine TSPY |
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| Authors: | Tanja Vogel Holly Boettger-Tong Indrajit Nanda Frank Dechend Alexander I Agulnik Colin E Bishop Michael Schmid Jorg Schmidtke |
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| Institution: | (1) Institute of Human Genetics, Medizinische Hochschule Hannover, D-30623 Hannover, Germany;(2) Department of Obstetrics and Gynecology, Baylor College of Medicine Houston, TX 77030, USA;(3) Institute of Human Genetics, Universitat Wurzburg, Am Hubland, D-97074 Wurzburg, Germany |
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| Abstract: | Sequences homologous to human and bovine TSPY were isolated from M. musculus testicular cDNA, and a nearly full-length gene was polymerase chain reaction (PCR) amplified from mouse genomic DNA. This gene is apparently non-functional. Contrary to the situation encountered in species along the primate and artiodactyl lineages, in which TSPY is moderately repetitive, murine Tspy appears to be single copy. Murine Tspy is located on Yp, i.e. in the same syntenic group as in man. Sequence comparisons of murine, human and bovine TSPY exons suggest that TSPY became non-functional during rodent evolution. |
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| Keywords: | murine TSPY Y chromosome |
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