刺五加注射液对早期糖尿病肾脏病变及血浆、尿内皮素的影响

目的：观察刺五加注射液对早期糖尿病肾病（DN）尿微量白蛋白及肾脏内皮素代谢的影响，探索刺五加防治DN的机制。方法：47例无高血压、持续微量白蛋白尿的2型糖尿病患者随机分为刺五加治疗组（治疗组）和常规治疗组（对照组），疗程8周。治疗前后观察尿白蛋白排泄率（UAE），血浆内皮素（ET）及尿ET等指标。结果：刺五加治疗8周后，DN患者UAE、血浆ET及尿ET排泄量均有明显下降（P＜0.01），而常规治疗 组无明显变化。相关性分析提示UAE的下降与尿、血浆 ET降低呈机相关（r=0.72,P<0.01和r=0.63,P<0.01）。结论：刺五加注射液对DN的保护作用可能与通过对肾脏局部 抑制ET合成密切相关。

Effect of Acanthopanax Senticosus Injection on Plasma and Urinary Endothelin in Early Stage of Diabetic Nephropathy

Objective: To explore the mechanism of Acanthopanax senticosus (AS) on diabetic nephropathy (DN) patients by observing its effect on urinary albumin excretion (UAE) and renal endothelin (ET) metabolism. Methods: Forty seven patients of diabetes mellitus (DM) type 2 with persistent microalbuminuria and normotension were randomly divided into two groups, the conventional treatment group (control group) and the AS treatment group. The treatment course was 8 weeks. The changes of UAE, plasma and urinary ET levels before and after treatment were observed. Results: Levels of UAE, plasma and urinary ET lowered significantly (P<0 01) in the AS groups, while no significant change was shown in the control group. By correlation analysis, the decrement of UAE was positively correlated with the decrement of urinary and plasma ET levels (r=0 72,P<0 01 and r=0 63,P<0 01). Conclusion: The protective effect of AS injection on DN is probably correlated with its inhibition on ET synthesis in kidney.