Experimental studies on the protective efficacy of a Pseudomonas aeruginosa vaccine

Pseudomonas aeruginosa vaccine (PV) containing cell proteins with molecular weight (M_r) 20 000–100 000 and up to 0.08% ( ) admixture of lipopolysaccharide was obtained by water—salt extraction and subsequent ultrafiltration. PV protects mice against experimental P. aeruginosa infection, stimulates production of specific protective antibodies in rabbit and does not provoke obvious toxicity in laboratory animals.