| 地奥心血康对大鼠实验性心肌缺血的保护作用 |
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| 引用本文： | 周春阳.地奥心血康对大鼠实验性心肌缺血的保护作用[J].川北医学院学报,1998,13(2):8-10. |
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| 作者姓名： | 周春阳 |
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| 作者单位： | Zhou Chunyang et alDepartment of Pharmacology，North Sichuan Medical College 637000 |
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| 摘 要： | 研究地奥心血康对大鼠实验性心肌缺血的影响。方法：结扎ｗｉｓｔａｒ大鼠左冠状动脉造成急性心肌缺血，设缺血对照组（生理盐水）、地奥心血康组（地奥心血康０．１０ｇ／ｋｇ），阳性药普萘洛尔组（普萘洛尔０．０１ｇ／ｋｇ），各组均在结扎冠脉１５ｍｉｎ后经十二指肠给药，记录给药前后不同时间胸前多导联心电图（９个点），以ΣＳＴ和ＮＳＴ来反映心肌缺血程度和范围，结扎冠脉３ｈ，摘取心脏，用Ｎ—ＢＴ染色确定心肌梗塞面积。结果：地奥心血康０１０ｇ／ｋｇ在３０、６０、１２０、１８０ｍｉｎ使ΣＳＴ分别下降２４％、２９％、３０％、２７％（与对照组比Ｐ＜０．０１、Ｐ＜０．０５）；使ＮＳＴ降低１６％、１７％、１６％、１７％（与对照组比Ｐ＜０．０１）持续１８０ｍｉｎ，使梗塞面积由对照组的１５１４％降到９．６０％（Ｐ＜０．０５）。结论：地奥心血康可降低大鼠实验性心肌缺血程度和缺血范围，减少梗塞面积。
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| 关 键 词： | 地奥心血康 心肌缺血 普萘洛尔 |
Protective Effects of Di-ao-xin-xue-kang onExperimental Myocardial Ischemia in Rats |
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| Abstract: | おIM:To study the effects of Di-ao-xin-xue-kang (DAXXK) on experimental myocardial ischemia in rats.METHOD:Acute myocardial ischemia model was performed with left anterior descending(LAD) occlusion in wistar rat heart.ST and NST of electrocardiograph(ECG) were used to evaluate myocardial ischmic extent and region,respectively.Myocardial infarction area was determined by NBT dying.RESULTS DAXXK 0.10 g/kg could reduce ST 24%,29%,30%,27% at 30,60,120,180min after LAD occlusion (P<0.01,P<0.05 compared with control group) and NST 16%,17%,16%,17%(P<0.01),respectively.Myocardial infarction district was decreased from 15.14% to 9.60% (P<0.05).Conclusion:DAXXK could reduce myocardial ischemia extent,region and myocardial infarction area in experimental ischemic rat hearts. |
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| Keywords: | Di-ao-xin-xue-kang Propranolol Myocardial ischemia LAD occlusion |
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