Dynamic changes in the numbers of different subsets of peripheral blood NK cells in patients with systemic lupus erythematosus following classic therapy |
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| Authors: | Hongshuang Ma Ling Zhao Zhenyu Jiang Yanfang Jiang Li Feng Zhuang Ye |
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| Institution: | 1. Department of Rheumatology, The First Hospital, Jilin University, Changchun, 130021, China
2. Key Laboratory for Zoonosis Research, Ministry of Education, The First Hospital, Jilin University, Changchun, 130032, China
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| Abstract: | Imbalance of natural killer (NK) cells is associated with the development of systemic lupus erythematosus (SLE). However, little is known about the dynamic changes on NK cells following therapy. This study aimed at examining the impact of classic therapies on the numbers of different subsets of NK cells in new-onset SLE patients. The numbers of different subsets of peripheral blood NK cells in 24 new-onset SLE patients before, 4 and 12 weeks post the classic therapies, and 7 healthy controls were determined by flow cytometry. The potential correlation between the numbers of NK cells and the values of clinical measures was analyzed. In comparison with that before treatment, the numbers of NK, NKG2C+, and KIR2DL3+ NK cells were significantly increased while the numbers of NKp46+ and NKG2A?+?NK cells significantly decreased at 4 and/or 12 weeks post the treatment only in the drug well-responding patients, but not in those poor responders (P?
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