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Lung function of preterm infants before and after viral infections |
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| Authors: | Simon B Drysdale Jessica Lo Michael Prendergast Mireia Alcazar Theresa Wilson Mark Zuckerman Melvyn Smith Simon Broughton Gerrard F Rafferty Janet L Peacock Sebastian L Johnston Anne Greenough |
| Institution: | 1. Division of Asthma, Allergy and Lung Biology, King’s College London, London, UK 2. Division of Health and Social Care Research, King’s College London, London, UK 3. NIHR Biomedical Research Centre at Guy’s and St Thomas’ NHS Foundation Trust and King’s College London, London, UK 4. South London Specialist Virology Centre & Health Protection Agency London Regional Laboratory, King’s College Hospital, London, UK 5. Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, London, UK 6. Neonatal Intensive Care Centre, 4th Floor Golden Jubilee Wing, King’s College Hospital, Denmark Hill, London, SE5 9RS, UK |
| Abstract: | Our aim was to determine whether viral lower respiratory tract infections (LRTIs) adversely affect prematurely born infants’ lung function at follow up. Seventy infants, median gestational age 34 (range, 24–35)?weeks were prospectively followed; 32 had an RSV (n?=?14) or another respiratory viral (n?=?18) LRTI (viral LRTI group) and 38 had no LRTI (no LRTI group). Six of the viral LRTI and five of the no LRTI group had been hospitalised. Nasopharyngeal aspirates (NPAs) obtained whenever the infants had an LRTI. Lung function (functional residual capacity FRCHe], compliance Crs] and resistance Rrs] of the respiratory system) was measured at 36 weeks postmenstrual age (PMA) and 1 year corrected. At 1 year, lung volume (FRCpleth) and airways resistance (Raw) were also assessed. There were no significant differences in the lung function of the two groups at 36 weeks PMA but at 1 year, the viral LRTI compared to the no LRTI group had a higher mean Raw (23 versus 17 cm H2O/l/s, p?=?0.0068), the differences remained significant after adjustment. Conclusion: These results suggest viral LRTIs, regardless of whether hospitalisation is required, adversely affect prematurely born infants’ airway resistance at follow up. |
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