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Serum and Salivary Matrix Metalloproteinases,Neutrophil Elastase,Myeloperoxidase in Patients with Chronic or Aggressive Periodontitis |
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| Authors: | Nejat Nizam Pınar Gümüş Jari Pitkänen Taina Tervahartiala Timo Sorsa Nurcan Buduneli |
| Affiliation: | 1. Department of Periodontology, School of Dentistry, Ege University, 35100, Bornova, ?zmir, Turkey 2. Department of Oral and Maxillofacial Diseases, Helsinki University Hospital, Institute of Dentistry, University of Helsinki, Helsinki, Finland 3. Division of Periodontology, Department of Dental Medicine, Karolinska Institute, Karolinska University Hospital Solna N3:06, 17 176, Stockhom, Sweden |
| Abstract: | Salivary, serum matrix metalloproteinase-8 (MMP-8), tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), neutrophil elastase (NE), and myeloperoxidase (MPO) levels were investigated in generalized chronic periodontitis (GCP), generalized aggressive periodontitis (GAgP), and healthy groups. Whole-mouth clinical periodontal measurements were recorded. Salivary, serum concentrations of MMP-8, MPO, TIMP-1, and NE were determined by immunofluorometric assay or ELISA in 18 patients with GCP, 23 patients with GAgP, 18 individuals with healthy periodontium. Patients in the GAgP group were younger than the other groups (p?p?TIMP-1 concentrations were lower in the periodontitis groups than the controls (p? |
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