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Serial N-terminal pro-brain natriuretic peptide measurement as a predictor of significant patent ductus arteriosus in preterm infants beyond the first week of life |
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| Authors: | Johannes Buca Letshwiti Jan Sirc Ruth O’Kelly Jan Miletin |
| Institution: | 1. Neonatal Intensive Care Unit, Coombe Women and Infants University Hospital, Dublin, Ireland 2. Neonatal Intensive Care Unit, Institute for the Care of Mother and Child, Prague, Czech Republic 3. Biochemistry Department, Coombe Women and Infants University Hospital, Dublin, Ireland 4. Department of Paediatrics, UCD School of Medicine and Medical Sciences, Dublin, Ireland |
| Abstract: | The aim of the study was to assess the role of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentration as a predictor of patent ductus arteriosus (PDA) in very low birth weight infants beyond the first week of life. This was a prospective observational study; newborns with a birth weight?Echocardiography and NT-proBNP levels were repeated at weekly intervals. The primary outcome was correlation between PDA and NT-proBNP level and between measurements of PDA significance and NT-proBNP. Sixty-nine neonates were enrolled following parental consent. The mean birth weight was 1119?±?257 g and mean gestational age was 28.6?±?2.6 weeks. Median NT-proBNP level on day seven was 11469 ng/l in infants with a PDA vs. 898 ng/l in infants without a PDA (p?Conclusion: NT-proBNP concentration is significantly increased in infants with a PDA and correlates well with PDA diameter in the first three weeks of life. |
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