| 前列腺素合成酶2在前列腺癌和前列腺增生中的表达及其意义 |
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| 引用本文： | 臧桐,孙凤岭,李瑛,杨同君,邓永江,杨学辉. 前列腺素合成酶2在前列腺癌和前列腺增生中的表达及其意义[J]. 中华外科杂志, 2001, 39(9): 702-703,W002 |
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| 作者姓名： | 臧桐 孙凤岭 李瑛 杨同君 邓永江 杨学辉 |
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| 作者单位： | 北京军区总医院泌尿外科 |
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| 摘 要： | 目的研究前列腺素合成酶(COX)-2在前列腺癌和前列腺增生组织中的表达及与临床的关系.方法随机选择42份前列腺增生和16份前列腺癌患者的手术标本,从定性和定量两个方面分别采用免疫组织化学和蛋白印记方法对COX-2蛋白的表达进行研究.结果16份前列腺癌标本中,15份COX-2呈阳性表达,占93.8%;42份前列腺增生的组织中,只有11份有COX-2的表达,占26%,两者差异有非常显著意义(直接概率法P＜0.01).且COX-2高表达的前列腺癌患者预后不佳.结论COX-2在前列腺癌组织中表达增强,且与癌的临床分期有关.
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| 关 键 词： | 前列腺肿瘤 前列腺增生 免疫组织化学 免疫蛋白印记法 前列腺素合成酶 |
Expression of COX-2 in prostatic cancer and benign prostatic hyperplasia |
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| ZANG Tong,SUN Fengling,LI Ying,et al.. Expression of COX-2 in prostatic cancer and benign prostatic hyperplasia[J]. Chinese Journal of Surgery, 2001, 39(9): 702-703,W002 |
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| Authors: | ZANG Tong SUN Fengling LI Ying et al. |
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| Affiliation: | Department of Urologic Surgery, Beijing Military General Hospital, Beijing 100700, China. |
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| Abstract: | Objective To investigate the expression of COX 2 in and benign prostatic hyperplasia and prostate cancer and its clinical implications. Methods Forty two patients with and benign prostatic hyperplasia and 16 with prostate cancer were studied by immunohischemistry and western blot. Results Immunohischemiscal study showed positive results in 15 of the 16 patients and 11 of the 42 patients. Western blot showed that the expression of COX 2 was higher in prostate cancer than in and benign prostatic hyperplasia tissues( P <0 01). Conclusion Overexpression of COX 2 in prostate cancer may be related to the stageing of prostate cancer. |
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| Keywords: | Prostatic neoplasms Prostaglandin-endoperoxide synthase Prostatic hyperplasia Immunohistochemistry |
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