化学药物刺激兔延髓腹外侧对动脉血压的调制作用

本试验用兔25只,采用颈前暴露延髓术,观察谷氨酸及甘氨酸刺激兔延髓腹外侧区对动脉血压的影响。结果表明:(1)药液滤纸贴附于双侧 S 区,L—谷氨酸引起血压明显上升,最大效应达基础血压的134.4±3.8%;甘氨酸引起动脉血压明显下降,最大效应达基础血压的72.2±4.0%,两者与对照组比较均有极显著差异(P<0.01)。(2)向兔延髓神经细胞群微量匀速注射此二种药物时,L—谷氨酸引起动脉血压明显上升,最大效应达基础血压的114.7±6.1%(P<0.05);甘氨酸引起血压明显下降,最大效应达基础血压的75.2±4.2%(P<0.01)。(3)将上述两种药液微量注射到兔延髓神经细胞群的尾部,L—谷氨酸则引起动脉血压下降(P<0.05),甘氨酸引起动脉血压上升(P<0.01)。

EFFECTS OF CHEMICAL DRUGS ON BLOOD PRESSURE CONTROL BY STIMULATION OF VENTROLATERAL MEDULLA OF RABBIT

Using the method of transthroat exposuring of ventrolateral medulla,the effects of glutamic acid and glycine on the blood pressure were observed in 25 rabbits.The resulls suggest that:(1)when the filter papar with glutamic acid solution attaches to the surface of both“S”areas,the blood pressure raises obviously with the most effect 134.4±3.0% of basal blood pressure;When these with glycine,the blood pressure decreases obviously with the most effect 72.2±4.0% of basal bleed pressure. Both groups have significant difference(p<0.001)compared with the control group. (2)when the uniform microinjection with glutamic acid administers to the both“S” areas,the blood pressure raises obviously with the most effect 114.7±6.1% of basal blood pressure (p<0.05).The uniform microinjection with glycine decreases the blood pressure with the most effect 75.2+4.2% of basal blood pressure (p<0.01).(3) when the uniform microinjection with glutamic acid administers to the cells of caudal ven- trolateral medulla,the blood pressure falls(p<0.05);when that of uniform microi- njection with glycine the blood Pressure raises obviously(p<0.01).