| 鼠神经生长因子治疗糖尿病周围神经病变35例临床观察 |
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| 引用本文： | 郭振元,刘云爱. 鼠神经生长因子治疗糖尿病周围神经病变35例临床观察[J]. 卒中与神经疾病, 2011, 18(6): 364-366. DOI: 10.3969/j.issn.1007-0478.2011.06.012 |
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| 作者姓名： | 郭振元 刘云爱 |
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| 作者单位： | 山东省兖州市人民医院,272100 |
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| 摘 要： | 目的观察鼠神经生长因子治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的疗效及安全性。方法将70例糖尿病周围神经病变患者随机分为两组,对照组35例常规给予糖尿病饮食,用胰岛素或口服降糖药控制血糖;维生素B1100mg,肌肉注射,1次/d;维生素B120.5mg,肌肉注射,1次/d;治疗组35例在对照组治疗基础上加用鼠神经生长因子注射液30μg,肌肉注射,1次/d。两组疗程均为21 d。两组均在治疗前后分别记录症状及体征、肌电图测腓总神经(common peroneal nerve)的MNCV及SNCV、并测定高敏C-反应蛋白(high-sensitivity C-reactive protein,hs-CRP)水平。结果治疗组总有效率显著高于对照组(P<0.05),治疗组各项神经传导速度显著高于对照组(P<0.05),治疗后治疗组hs-CRP水平较对照组显著下降(P<0.05)。结论鼠神经生长因子治疗糖尿病周围神经病变安全有效。
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| 关 键 词： | 鼠神经生长因子 糖尿病周围神经病变 疗效 |
The clinical observation of rat nerve growth factor for treatment of 35 cases with diabetic peripheral neuropathy |
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| Guo Zhenyuan,Liu Yunai. The clinical observation of rat nerve growth factor for treatment of 35 cases with diabetic peripheral neuropathy[J]. Stroke and Nervous Diseases, 2011, 18(6): 364-366. DOI: 10.3969/j.issn.1007-0478.2011.06.012 |
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| Authors: | Guo Zhenyuan Liu Yunai |
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| Affiliation: | Guo Zhenyuan,Liu Yunai.The Hospital in County of Yanzhou,Shandong Province,272100 |
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| Abstract: | Objective To observe the efficacy and safety of the rat nerve growth factor in the treatment to diabetic peripheral neuropathy(DPN). Methods 70 patients with DPN were randomly divided into two groups,the control goup(35 cases) were given to diabetes diet,use of insulin or oral hypoglycemic agents to control blood sugar,vitamin B1 100mg and vitamin B12 0.5mg intramuscular to cure neuropathy,qd;the treatment group(35 cases) were given the treatment of rat nerve growth factor injection 30ug based on the contro... |
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| Keywords: | Rat nerve growth factor Diabetic peripheral neuropathy Effect |
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