慢性病毒性肝炎中转化生长因子α的水平变化

目的 研究慢性病毒性肝炎患者血清TGF-a水平变化及其与肝功能生化指标、预后等的关系,探讨TGF-a作为反映慢性肝炎患者肝细胞损害严重程度或再生情况指标的可行性. 方法 采用ELISA 方法对26例慢性重型肝炎患者、30例慢性乙型肝炎患者及20例正常人的血清TGF-a水平进行检测,并结合临床资料进行分析. 结果 (1)慢性乙型肝炎组血清TGF-a水平较对照组升高(P＜0.01).(2)不同预后的慢性重型肝炎患者血清TGF-a水平存在差异,有效组(包括临床治愈出院、好转出院)血清TGF-a含量较正常对照组显著升高(P＜0.05),无效组(包括过渡到肝移植、自动出院、死亡)略降低但差异无统计学意义(P＞0.05).(3)在慢性乙型肝炎组中,血清TGF-a含量与ALT、AST、总胆红素(TBil)及白蛋白(ALB)均无相关性;在慢性重型肝炎组中,血清TGF-α含量与ALT、AST、TBil、ALB及凝血酶原时间(PT)均无相关性.血清TGF-a含量与甲胎蛋白(AFP)呈正相关(rs=0.763,P＜0.01). 结论 (1)不同预后的慢性重型肝炎患者血清TGF-a水平存在差异;(2)血清TGF-a水平在一定程度上能反映肝细胞的再生情况.

The serum level of transforming growth factor-alpha in chronic viral hepatitis

Objective To investigate the serum level of TGF-α in chronic hepatitis patients and the relation between TGF-α and hepatic function index, regeneration as well as prognosis. Methods The serum level of TGF-α in 26with chronic severe hepatitis patients, 30 chronic hepatitis B patients and 20 healthy individual (control group)was detected by ELISA. Results (1)Serum TGF-α level in chronic hepatitis B patients was much higher than in control group( P＜0.01). (2)There were differences in serum level of TGF-α among the chronic severe hepatitis patients with different prognosis: TGF-αlevel in good prognosis patients was much higher than in healthy individual(P＜0.05), TGF-α level in poor prognosis was slightly decreased, but there was no statistical significance(P＞0.05)between the patients and healthy individuals. (3)In group with chronic hepatitis B,the serum TGF-α level had no relation with the serum level of ALT, AST, ALB and Tbil, and in group with chronic severe hepatitis, the serum level of TGF-α also had no relation with theserum level of ALT, PI, Tbil, ALB and prothrombin time(PT). But the serum level of TGF-α was positive correlation with AFP(rs=0.763, P＜0.01). Conclusions (1) There are differences among the serum TGF-α level in chronic severe hepatitis patients with different prognosis. (2)In a sense, the serum TGF-α level can reflect the state of hepatocyte regeneration.