Ferrihemoglobin and kidney lesions in rats produced by 4-aminophenol or 4-dimethylaminophenol |
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| Authors: | M Kiese L Szinicz N Thiel N Weger |
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| Institution: | (1) Pharmakologisohes Institut der Universität München, München, FRG |
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| Abstract: | 4-Dimethylaminophenol hydrochloride (DMAP), 20 mg/kg i.V., was found to oxidize in rats as much as 50% of the hemoglobin to ferrihemoglobin but did not cause kidney lesions. 4-Aminophenol hydrochloride, 400mg/kg i.V., oxidized only 25% of the hemoglobin and produced large tubular necroses. In highly toxic doses only, e.g., twice the LD50, DMAP also produced tubular necroses.
Abbreviations Used DMAP
4-Dimethylaminophenol hydrochloride
- AP
4-Aminophenol hydrochloride |
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| Keywords: | 4-Dimethylaminophenol 4-aminophenol Ferrihemoglobin Kidney lesions |
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