| 初发鼻咽癌差异基因的染色体定位及功能分析 |
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| 引用本文： | 林森,黄振校,李文峰,张春鸿,方潇碧,廖志苏. 初发鼻咽癌差异基因的染色体定位及功能分析[J]. 中国耳鼻咽喉头颈外科, 2010, 17(9): 455-457 |
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| 作者姓名： | 林森 黄振校 李文峰 张春鸿 方潇碧 廖志苏 |
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| 作者单位： | 温州医学院附属第一医院,耳鼻咽喉科,浙江,温州,325000;温州医学院附属第一医院,放疗科,浙江,温州,325000 |
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| 基金项目： | 浙江省科技厅科技攻关项目基金(2007C23G2090017); 温州市科技局科研基金资助项目(Y2005AOB)联合资助 |
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| 摘 要： | 目的利用基因芯片技术探索初发鼻咽癌（primary nasopharyngeal carcinoma,pNPC）与鼻咽黏膜慢性炎症组织（chronic nasopharyngitis tissue）差异基因的染色体定位和功能分析。方法用Affymetrix Gene1.0ST芯片检测pNPC与鼻咽黏膜慢性炎症组织基因表达谱差异,并利用生物信息学方法对差异基因进行染色体定位和功能分析。结果差异倍数3倍以上共有102个基因,其中表达上调25个,表达下调77个;差异基因染色体定位分析,发现5个差异基因未知其定位,其余97个差异基因在1号染色体上分布最多,包含16个,其次为3号染色体,包含13个;从差异基因功能分类看,属于酶活性基因最多,其余依次为蛋白结合、免疫、钙黏合等,以上4大类共占差异基因总数65.6%。结论 pNPC差异基因散在分布在各染色体,以1、3号染色体最多;4大类（酶活性、蛋白结合、免疫相关、钙黏合）相关基因异常在癌变过程中发挥重要作用。
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| 关 键 词： | 基因表达谱 染色体定位 初发鼻咽癌 分子功能 |
Function and chromosome location of differentially expressed genes in primary nasopharyngeal carcinoma |
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| LIN Sen,HUANG Zhenxiao,LI Wenfeng,ZHANG Chunhong,FANG Xiaobi,LIAO Zhisu. Function and chromosome location of differentially expressed genes in primary nasopharyngeal carcinoma[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2010, 17(9): 455-457 |
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| Authors: | LIN Sen HUANG Zhenxiao LI Wenfeng ZHANG Chunhong FANG Xiaobi LIAO Zhisu |
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| Affiliation: | LIN Sen1,HUANG Zhenxiao1,LI Wenfeng2,ZHANG Chunhong1,FANG Xiaobi1,LIAO Zhisu1 (1 Department of Otolaryngology,2 Department of Radiotherapy,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou,Zhejiang,325000,China) |
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| Abstract: | OBJECTIVE To explore the function and chromosome location of differentially expressed Genes between primary nasopharyngeal carcinoma and chronic nasopharyngitis tissue. METHODS Affymetrix Gene 1.0 ST gene chip was used to examine the differentially expressed genes between primary nasopharyngeal carcinoma tissues and chronic nasopharyngitis tissues. Their chromosome location and function was characterized by bioinformatics. RESULTS A difference in expression levels of more than 3 times were found in 102 gene... |
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| Keywords: | Gene Expression Profiling Chromosome Positioning primary nasopharyngeal carcinoma molecular function |
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