| 不同炼制温度和用量的羊脂油制淫羊藿对肾阳虚大鼠的影响 |
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| 引用本文： | 李寅超,黄兰岚,赵宜红,王彩芳,李娆娆,谷艳,刘学武,黄璐琦,王随华. 不同炼制温度和用量的羊脂油制淫羊藿对肾阳虚大鼠的影响[J]. 中国中药杂志, 2011, 36(16): 2250-2254 |
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| 作者姓名： | 李寅超 黄兰岚 赵宜红 王彩芳 李娆娆 谷艳 刘学武 黄璐琦 王随华 |
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| 作者单位： | 1. 郑州大学药学院,河南郑州,450001
2. 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 国家科技部科研院所社会公益研究专项(2005D1B1J169-01);中国中医科学院传承博士后项目(63489) |
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| 摘 要： | 目的:考察不同炼制温度和用量的羊脂油制淫羊藿对肾阳虚大鼠的影响.方法:采用皮下注射皮质酮(CORT)建立肾阳虚大鼠模型,以淫羊藿总黄酮为阳性对照,以症状体征、动物抓力、组织病理学检查、血清睾酮含量等为评价指标,3种制淫羊藿(羊脂油炼制温度与加入量分别为250℃,30％；120℃,30％；120℃,20％)和生淫羊藿经水提取灌胃给药,考察不同样品对肾阳虚大鼠的药理作用.结果:3个炮制品均能不同程度地增强生品的温肾壮阳作用,其中以120℃,30％的制淫羊藿增强效果最佳.其作用机制可能与改善肾阳虚证大鼠下丘脑-垂体-肾上腺-胸腺(HPAT)轴病理改变和功能抑制状态有关.结论:辅料羊脂油的炼制温度影响辅料质量,进而影响饮片药效.本试验结果为进一步阐明制淫羊藿炮制原理及建立炮制辅料的国家标准提供实验数据.
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| 关 键 词： | 羊脂油 制淫羊藿 肾阳虚 炮制辅料 |
| 收稿时间： | 2010-08-13 |
Effect of Epimedii Folium processed with different refining temperatures and amounts of sheep's oil on kidney-yang deficiency rats |
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| LI Yinchao,HUANG Lanlan,ZHAO Yihong,WANG Caifang,LI Raorao,GU Yan,LIU Xuewu,HUANG Luqi and WANG Suihua. Effect of Epimedii Folium processed with different refining temperatures and amounts of sheep's oil on kidney-yang deficiency rats[J]. China Journal of Chinese Materia Medica, 2011, 36(16): 2250-2254 |
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| Authors: | LI Yinchao HUANG Lanlan ZHAO Yihong WANG Caifang LI Raorao GU Yan LIU Xuewu HUANG Luqi WANG Suihua |
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| Affiliation: | Pharmacy College of Zhengzhou University, Zhengzhou 450001, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Pharmacy College of Zhengzhou University, Zhengzhou 450001, China;Pharmacy College of Zhengzhou University, Zhengzhou 450001, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Pharmacy College of Zhengzhou University, Zhengzhou 450001, China;Pharmacy College of Zhengzhou University, Zhengzhou 450001, China;Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;Pharmacy College of Zhengzhou University, Zhengzhou 450001, China |
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| Abstract: | |
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| Keywords: | sheep's oil processed Epimedii Folium kidney yang deficiency processing excipients |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ |
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