| 番茄红素对动脉粥样硬化家兔血脂及低密度脂蛋白受体mRNA表达的影响 |
| |
| 引用本文： | 覃伟,钱妍.番茄红素对动脉粥样硬化家兔血脂及低密度脂蛋白受体mRNA表达的影响[J].中国医院药学杂志,2010(3). |
| |
| 作者姓名： | 覃伟 钱妍 |
| |
| 作者单位： | 重庆医科大学附属第二医院; |
| |
| 基金项目： | 重庆市卫生局医学科学技术基金项目(编号:07-2-109) |
| |
| 摘 要： | 目的:通过建立家兔动脉粥样硬化模型,观察低密度脂蛋白受体(LDLR)mRNA在实验性动脉粥样硬化家兔主动脉平滑肌细胞和心肌细胞的表达及番茄红素对其表达的影响。方法:采用高脂饲料建立家兔动脉粥样硬化模型,造模60d,从第61d起给予番茄红素进行干预,连续用药40d后,测定血清脂质总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)]含量,采用RT-PCR法检测LDLR在主动脉平滑肌细胞和心肌细胞mRNA的表达。所有数据经SPSS13.0软件进行统计分析。结果:番茄红素大剂量组家兔血清TG含量明显低于模型组(P<0.05),而番茄红素小剂量组与模型组比较差异无显著性。RT-PCR结果表明番茄红素能够抑制家兔主动脉和心脏LDLR mRNA的表达。结论:番茄红素对动脉粥样硬化家兔的血脂和脂蛋白代谢紊乱具有调节作用,其作用机制可能与降低TG浓度、抑制LDLR的表达有关。
|
| 关 键 词： | 番茄红素 动脉粥样硬化 低密度脂蛋白受体 家兔 |
Effect of lycopene on the expression of low density lipoprotein receptor mRNA in atherosclerotic rabbits |
| |
| QIN Wei,QIAN Yan.Effect of lycopene on the expression of low density lipoprotein receptor mRNA in atherosclerotic rabbits[J].Chinese Journal of Hospital Pharmacy,2010(3). |
| |
| Authors: | QIN Wei QIAN Yan |
| |
| Institution: | QIN Wei,QIAN Yan(The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China) |
| |
| Abstract: | OBJECTIVE To explore the pharmacological mechanism of lycopene against atherosclerosis(AS) by detection of the expression of low density lipoprotein receptor(LDLR) mRNA expression on the myocardial cells and aortic smooth cells.METHODS AS animal models were randomized into five groups.The groups were fed with high fatty diet for 60 d except the normal group.Lycopene with different doses was given by intra-gastric administration from the 61d to the end of the experiment.The blood samples were analyzed for to... |
| |
| Keywords: | lycopene atherosclerosis low density lipoprotein receptor(LDLR) rabbits |
| 本文献已被 CNKI 等数据库收录！ |
