Acute exposure of rhesus monkeys to dieldrin: Effect on lipid metabolism

Rhesus monkeys have been administered a single oral dose of dieldrin (20 mg/kg body wt.) and their lipid metabolism has been investigated 24 hr after the treatment. There was an increased accumulation of lipids, particularly triacylglycerols in adipose tissue, liver, and kidney, while the lipid profile of plasma did not change. An increased conversion of [U-¹⁴C]glucose into hepatic total lipids and triacylglycerols was observed. Lipolytic activity in tissues and postheparin plasma was, however, elevated. No change was found in the endogenous lipid secretion from the liver and in the removal rate of lipids from the circulation. Thus accumulation of triacylglycerols in the tissues on dieldrin administration seems to be due to increased lipid synthesis.