Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans |
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Authors: | Glickstein Lisa Moore Brian Bledsoe Tara Damle Nitin Sikand Vijay Steere Allen C |
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Institution: | Division of Rheumatology/Immunology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA. lglickstein@partners.org |
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Abstract: | In a study of cytokine production ex vivo by Borrelia burgdorferi-stimulated peripheral blood mononuclear cells from 27 patients with culture-positive erythema migrans, production of inflammatory cytokines predominated, particularly gamma interferon and, to a lesser degree, tumor necrosis factor alpha. In contrast, with the exception of interleukin-13, anti-inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early Lyme disease often induce a strong inflammatory response. |
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