The modulatory effect of diltiazem on human in vitro alloreactivity when used alone or in combination with cyclosporin A and/or methylprednisolone |
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Authors: | A D'Ambrosio G Segoloni F Quintieri |
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Institution: | (1) Laboratorio di Immunologia, Istituto Superiore di Sanita`, Viale Regina Elena, 299, I-00 161 Rome, Italy Fax: + 39 6 4990 2709, IT |
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Abstract: | The calcium channel blocker diltiazem is often included in post-transplant regimens in combination with other immunosuppressive
drugs such as cyclosporin A (CyA). It is primarily used because of its antinephrotoxic and antihypertensive effects, so that
undesirable side effects induced by the immunosuppressive therapy can be reduced. Its alleged ability to induce direct immunosuppression
may explain the encouraging results from its clinical use and would appear to encourage a much wider use of this drug. The
present study shows the effect of diltiazem on the human in vitro alloresponse when used alone or in combination with cyclosporin
A (CyA) and methylprednisolone (MP). The results show that, when administered alone, diltiazem exerts a suppressive effect,
but only at high, non-therapeutic doses. Interestingly, in combination with CyA or MP, diltiazem enhances the suppressive
effect of these two drugs on in vitro alloresponses at lower doses. This additional effect of diltiazem may contribute to
better graft survival in clinical transplantation.
Received: 26 February 1997 Received after revision: 9 June 1997 Accepted: 3 July 1997 |
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Keywords: | Diltiazem alloreactivity Immunosuppression diltiazem MLR diltiazem |
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