| 影响干粉吸入剂肺沉积的制剂因素 |
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| 引用本文： | 王晓波,袭荣刚,杨晓波,潘卫三,石焱,王一楠. 影响干粉吸入剂肺沉积的制剂因素[J]. 中国新药杂志, 2010, 0(7) |
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| 作者姓名： | 王晓波 袭荣刚 杨晓波 潘卫三 石焱 王一楠 |
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| 作者单位： | 中国人民解放军第210医院;沈阳药科大学;大连医科大学附属第一医院; |
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| 摘 要： | 干粉吸入剂的制剂因素包括药物粉末的处方组成、给药装置类型等,是影响药物肺沉积的主要因素。文中按照药物处方组成将干粉吸入剂分成无载体、药物-载体、药物-添加剂、药物-载体-添加剂4种类型,并分别对其影响肺沉积的制剂因素进行了分析。
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| 关 键 词： | 干粉吸入剂 肺沉积 制剂因素 喷雾干燥 干粉吸入装置 |
Influence of formulation excipients and physical characteristics on lung deposition of dry powder inhalations |
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| WANG Xiao-bo,,XI Rong-gang,YANG Xiao-bo,PAN Wei-san,SHI Yan,WANG Yi-nan. Influence of formulation excipients and physical characteristics on lung deposition of dry powder inhalations[J]. Chinese Journal of New Drugs, 2010, 0(7) |
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| Authors: | WANG Xiao-bo XI Rong-gang YANG Xiao-bo PAN Wei-san SHI Yan WANG Yi-nan |
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| Affiliation: | WANG Xiao-bo1,2,XI Rong-gang1,YANG Xiao-bo1,PAN Wei-san2,SHI Yan1,WANG Yi-nan3(1 The 210th Hospital of PLA,Dalian 116021,China,2 Shenyang Pharmaceutical University,Shenyang 110016,3 The First Affiliated Hospital of Dalian Medical University,Dalian 116011,China) |
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| Abstract: | The formulation factors,including physical characteristics of dry powder inhalations,excipients and dry powder inhalers,is very important in achieving adequate delivery of inhaled drug to lungs.Here dry powder inhalations are classified into following four types (carrier-free,drug-carrier,drug-additive and drug-carrier-additive) and analyzed. |
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| Keywords: | dry powder inhalations lung deposition formulation factor spray drying dry powder inhalers |
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