| 苯妥英钠与卡马西平在健康志愿者体内药物动力学相互作用 |
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| 引用本文： | 张若楠,瞿治平,俞丽云,吴永麟,张静华. 苯妥英钠与卡马西平在健康志愿者体内药物动力学相互作用[J]. 中国新药与临床杂志, 1991, 0(2) |
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| 作者姓名： | 张若楠 瞿治平 俞丽云 吴永麟 张静华 |
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| 作者单位： | 上海医科大学基础医学部法医学教研室，上海医科大学神经病学研究所，上海医科大学神经病学研究所，上海医科大学神经病学研究所，上海医科大学华山医院药剂科 上海 200032，上海 200040，上海 200040，上海 200040，上海 200040 |
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| 摘 要： | 应用高效液相色谱法测定16名健康志愿者单用和联用苯妥英钠和卡马西平的血浓度。动力学过程用一房室模型一级动力学拟合。首次报道中国人体内苯妥英钠和卡马西平相互作用引起的2药最大稳态浓度C_((ss)max),最小稳态浓度C_((ss)min),达峰时间T_(max),消除半衰期T_(1/2),药时曲线下面积AUC等动力学参数变化的资料。结果表明苯妥英钠使卡马西平的T_(1/2)明显缩短,而卡马西平则延长苯妥英钠的T_(1/2)。
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| 关 键 词： | 苯妥英 卡马西平 药物动力学 药物相互作用 |
The pharmacokinetic interactions of phenytoin and carbamazepine in healthy Chinese volunteers |
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| ZHANG Ruo-Nan. The pharmacokinetic interactions of phenytoin and carbamazepine in healthy Chinese volunteers[J]. Chinese Journal of New Drugs and Clinical Remedies, 1991, 0(2) |
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| Authors: | ZHANG Ruo-Nan |
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| Abstract: | The pharmacokinetic interactions between phenytoin (PHT) and car-bamazepine (CBZ) were studied with HPLC in 16 healthy volunteers by taking PHT or CBZ and then both. The kinetic courses were described by an open one-compartment model and first-order elimination. Thus, the pharmacokinetic parameters C(ss)max C(ss)min, Tmax, T and AUC under the interactions between PHT and CBZ in healthy Chinese volunteers were obtained. The results indicated that PHT made T of CBZ shorter significantly but CBZ prolonged T of PHT. |
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| Keywords: | phenytoin carbamazepine pharmacokinetics drug interactions |
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