盐酸戊乙奎醚(长托宁)治疗脓毒性休克的临床研究

目的观察盐酸戊乙奎醚(长托宁)在脓毒性休克治疗中的作用。方法收集40例符合脓毒性休克诊断标准的ICU住院患者,随机分为A,B,C,D四组,分别为654—2组,长托宁2 mg每小时重复一次,长托宁2 mg每6 h重复一次及长托宁6 mg每6 h一次,直至“莨菪化”或末梢开始改善后逐渐减量。观察给药后1 h、6 h、12 h时点患者心率、平均动脉压、瞳孔、末梢转暖时间、脉搏血氧饱和度、神志、肠鸣音及血乳酸含量变化。结果长托宁可明显改善休克患者微循环,给药次数少,几乎不增加心率、不抑制肠蠕动。结论长托宁是脓毒性休克患者较理想的血管活性药。

Clinical study on penehyclidine hydrochloride on treatment of septic shock

Objective To observe the action of penehyclidine hydrochloride on the treatment for septic shock. Methods Total 40 admitted patients for septic shock,were randomly divided into four groups,Group A:654-2 30 mg, Q 30 min;Group B:penehvclidine hydrochloride 2 mg,Q 1 h;Group C:penehyclidine hydrochloride 2 mg,Q 6 h; Group D:penehyclidine hydrochloride 6 mg,Q 6 h,The medication dosage was not abated until twig were improved.The heart rate (HR),mean arterial pressure (MAP),diameter of the pupil,the time and duration of the twig improvement, saturation of pulse oxygen (SpO_2),consciousness,intestinal sound and the level of lactolose in blood were observed. Results penehyclidine hydrochloride could improve the microcirculation in patients with septic shock.The administration time was few.It didn't make the heart rate increase and inhibit the intestinal motion.Conclusion Penehyclidine hydrochloride would be one of the ideal vasoactive drugs in treatment for septic shock.