黄耆的利尿与降压作用

给大白鼠皮下注射及麻醉狗静脉注射黄耆0.5克/公斤后,均可产生显著的利尿作用;给正常人口服0.2克/公斤后亦可产生显著的利尿作用.黄耆的利尿作用持续时间较长,给大白鼠皮下注射后,利尿作用可持续7天,连续给药7天后无耐受性.大白鼠皮下注射0.5克/公斤的利尿效价与氨茶碱0.05克/公斤及双氢氯噻嗪0.2毫克/公斤者相当.给麻醉狗静脉注射或灌胃黄耆0.5克/公斤后,均可引起明显的降压作用,重复静脉注射时出现快速耐受性.黄耆的毒性很小,给小白鼠灌胃75克/公斤无异常症状,小白鼠的半数致死量(腹腔注射)为40±5克/公斤,大白鼠慢性毒性试验未出现不良反应.

THE DIURETIC AND HYPOTENSIVE ACTION OF ASTRAGALUS MEMBRANACEUS BGE.

The root of Astragalus membranacesis Bge. is used in Chinese medicine as a cure for chronic renal edema. The present work was conducted to study its diuretic and some other related effects. A dose of 0.5 g/kg was found to have a marked diuretic action either in rats ad- ministered hypodermically or in anaesthetized dogs intravenously. Following oral ad- ministration to normal persons, it also showed a diuretic action. Such an action persisted for 7 days following a hypodermic injection into rats. No tolerance appeared on hypo- dermic injection in rats once daily for 7 days. The diuretic potency seen at 0.5 g/kg was similar to aminophyllin at 0.05 g/kg or hydrochlorothiazide at 0.2 mg/kg. The drug given intravenously or by stomach tube to anaesthetized dogs at 0.5 g/kg produced a remarkable fall of blood pressure. Repeated intravenous injection caused tachyphylaxis. A dose of 75 g/kg orally showed no toxic effect in mice. The LD₅₀ in mice by in- traperitoneal injection had been found to be 40±5g/kg. No side effect in rats was found on chronic toxicity test.