| 针刺对吗啡戒断后焦虑模型小鼠行为和脑内去甲肾上腺素含量的影响 |
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| 引用本文： | 周奇志,余曙光,吴俊梅,刘雨星,蒲艺,唐勇.针刺对吗啡戒断后焦虑模型小鼠行为和脑内去甲肾上腺素含量的影响[J].成都中医药大学学报,2003,26(1):40-42. |
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| 作者姓名： | 周奇志 余曙光 吴俊梅 刘雨星 蒲艺 唐勇 |
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| 作者单位： | 成都中医药大学,针灸推拿学院,四川,成都,610075 |
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| 基金项目： | 四川省中医管理局课题资助 (2 0 0 0 - 6 8) |
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| 摘 要： | 目的：探讨针刺对吗啡戒断后焦虑小鼠的作用效应和对脑内去甲肾上腺素（NE）的影响。方法：采用逐日递增法，皮下注射吗啡形成小鼠吗啡依赖后，给予纳络酮催促，建立吗啡戒断后焦虑模型。采用：“三阴交”电针治疗和T迷宫行为学测试的方法，观察针刺对吗啡戒断后焦虑小鼠的焦虑情绪和脑内去甲肾上腺素（NE）含量变化的影响。结果：1、针刺可使吗啡戒断后焦虑模型小鼠在闭臂滞留时间缩短（P＜0．05），在开臂滞留时间延长（P＜0．05）；2、针刺能明显降低模型组小鼠脑组织NE（P＜0．01）含量。结论：针刺可抑制吗啡戒断后所致的焦虑症状，其抗焦虑效应可能与针刺调节焦虑模型小鼠脑内NE的释放有关。
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| 关 键 词： | 针刺疗法 吗啡戒断 焦虑 去甲肾上腺素 |
| 文章编号： | 1004-0668(2003)01-0040-03 |
| 修稿时间： | 2002年7月28日 |
Influence of Acupuncture on Behavior and Brain Norepinephrine (NE) Content of Anxious Model Mice after Morphine Withdrawal |
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| ZHOU Qi zhi,YU Shu guang,Wu Jun mei,et al.Influence of Acupuncture on Behavior and Brain Norepinephrine (NE) Content of Anxious Model Mice after Morphine Withdrawal[J].Journal of Chengdu University of Traditional Chinese Medicine,2003,26(1):40-42. |
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| Authors: | ZHOU Qi zhi YU Shu guang Wu Jun mei |
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| Abstract: | Objective: Studying on influence of acupuncture on behavior and brain NE content of anxious model mice after morphine withdrawal.Method: Adopting subcutaneous injection of morphine with progressively increased dose till addicting, then stopping morphine and setting up anxious mice model. Acupuncturing the SanYinJiao point, observing the changes of mice behavior and brain NE content by applying T labyrinth praxiology.Result: 1. Acupuncture can make mice stay in closed arm shorter (P<0.05)and longer in open arm(P<0.05).2. Acupuncture can decrease obviously the NE content in model mice brain(P<0.01).Conclusion: Acupuncture can inhibit anxious symptom caused by morphine withdrawal, which may relate to acupuncture's function to adjust brain NE release. |
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| Keywords: | Acupuncture Morphine withdrawal anxiety NE |
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