多西他赛联合顺铂治疗中晚期非小细胞肺癌和乳腺癌临床观察

目的:探讨多西他赛联合顺铂治疗中晚期非小细胞肺癌和乳腺癌的疗效及毒副作用。方法:中晚期非小细胞肺癌43例和乳腺癌32例,应用多西他赛联合顺铂方案(多西他赛70 mg/m2 d₁,顺铂40 mg d_2~4,3周为1疗程)化疗2个疗程以上评价疗效。结果:非小细胞肺癌的缓解率(完全缓解+部分缓解)为27.9%,乳腺癌为31.3%;主要毒副作用均为白细胞减少和恶心、呕吐、肌肉酸痛、发热等,且Ⅳ度少见,未见明显肝肾毒性,差异均无统计学意义(P>0.05)。结论:多西他赛联合顺铂治疗中晚期非小细胞肺癌和乳腺癌的疗效和安全性均较好,毒副反应可以耐受。

A clinical trial of docetaxel plus cisplatin in treatment of advanced non-small cell lung cancer and breast cancer

Objective:The study was to evaluate the efficacy and tolerability of docetaxel plus cisplatin in the treatment of non-small cell lung cancer and breast cancer.Methods:Seventy-five patients were received docetaxel 70 mg/m2 d1 plus cisplatin 40 mg d2-4,and the plan was repeated every 3 weeks.All the patients had to received at least 2 cycles of chemotherapy.Results:The response rate of the study(CR+PR)was 29.3%(non-small lung cancer was 27.9%,breast cancer was 31.3%).The main toxicities were myelo suppression...