升清胶囊对人L-02肝细胞氧化损伤模型生化指标的影响 |
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引用本文: | 李炯,梁晓强,顾宏刚,朱培庭.升清胶囊对人L-02肝细胞氧化损伤模型生化指标的影响[J].四川中医,2013(7):39-41. |
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作者姓名: | 李炯 梁晓强 顾宏刚 朱培庭 |
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作者单位: | [1]上海中医药大学附属龙华医院普外科,上海200032 [2]上海中医药大学附属龙华医院中医外科研究所,上海200032 |
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基金项目: | 国家教育部高等学校博士点基金(20113107110002);上海市科委自然科学基金项目(No:11ZR1436800);上海市教委项目(No:2010JW36);上海市教委预算内科研项目(No:2011JW32);国家自然科学基金项目(No:81173267);上海市科委中药现代化专项(No:11DZ1972701);海派中医顾氏外科流派建设项目(No:ZYSNXD-CC-APGC-JD002). |
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摘 要: | 目的:研究升清胶囊对肝细胞氧化损伤模型生化指标的影响。方法:本实验分为正常组、模型组、空白血清组和升清胶囊药物血清组4组,空白血清组和升清胶囊药物血清组给予相应血清干预,观察4组相关生化指标(细胞外LDH,细胞内MDA、GSH和SOD)的变化。结果:LDH、MDA在模型组中达到较高的水平,而GSH、SOD活力处于较低的水平,相对于模型组,升清胶囊血清组细胞外LDH、细胞内MDA的含量降低(P〈0.01),细胞内SOD、GSH的含量增高(P〈0.01)。结论:表明升清胶囊可以减轻肝细胞的氧化损伤程度,提高肝细胞的抗氧化能力,有利于细胞损伤的修复。
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关 键 词: | 胆道疾病 自由基 升清胶囊 |
Influence of Biochemical Indicators on Human Liver Cell L-02 Oxidation Damage Model by Shengqing Capsule |
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Institution: | LI Jiong^1 , LIANG Xiaoqiang^2, GU Honggang^1 , et al. //1. Department of General Surgery, Longhua Hospital Affiliated to Shang- hai University of Traditional Chinese Medicine ( shanghai 200032, China) ; 2. Department of Research Institute of Traditional Chinese Medicine Surgery, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine (Shanghai 200032, China) |
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Abstract: | Objective: To discuss the influence of biochemical indicators on liver cell oxidation damage model by Shengqing Capsule. Methods: The experiment was divided into 4 groups (normal group, model group, controlled group and Shengqing group). Controlled group and Shengqing group were given corresponding serum. To observe the biochemical indicators (LDH, MDA, GSH and SOD). Results: The results of LDH and MDA reached a high level and the results of GSH and SOD reached a low level in model group. The results of LDH and MDA reached a lower level and the results of GSH and SOD reached a higher level in Shengqing group than in model group (P〈0.01). Conclusion: Shengqing Capsule can reduce the oxidation damage de gree and improve the antioxidation ability of liver cells. |
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Keywords: | Biliary disease Free radical Shengqing Capsule |
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