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Exercise intensity influences cell injury in rat hippocampal slices exposed to oxygen and glucose deprivation |
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| Authors: | Scopel Denise Fochesatto Cíntia Cimarosti Helena Rabbo Maristela Belló-Klein Adriane Salbego Christianne Netto Carlos Alexandre Siqueira Ionara Rodrigues |
| Affiliation: | aDepartamento de Bioquímica, RS, Brazil;bPrograma de Pós Graduação em Ciências Biológicas-Neurociências, RS, Brazil;cDepartamento de Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;dDepartamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil |
| Abstract: | We evaluated the effects of two levels of daily forced exercise intensity (moderate and high) in the treadmill over cell susceptibility to oxygen and glucose deprivation (OGD) in hippocampal slices from Wistar rats. Moderate exercise decreased lactate dehydrogenase (LDH) release after OGD, while a significant increase in LDH release was observed in the high intensity group submitted to OGD. Our data corroborate the hypothesis that higher training intensity exacerbates brain damage, while a moderate intensity reduces the injury caused by in vitro ischemia. |
| Keywords: | Exercise Susceptibility to ischemia Oxygen and glucose deprivation Hippocampal slices |
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