乙肝疫苗对单项抗-HBc、抗-HBe及抗-HBc均阳性者抗-HBs产生的探讨

目的]探讨接种乙肝疫苗对促进乙肝抗-HBc单项阳性及抗-HBe、抗HBc 2项同时阳性者产生抗-HBs的作用。方法]对抗-HBc单项阳性及抗-HBe、抗HBc 2项同时阳性者,进行乙肝疫苗接种。接种全程结束后1个月,抽血作抗-HBs检查。结果]接种乙肝疫苗后,抗-HBs总阳转率为92.59%,抗-HBc阳性者抗-HBs阳转率为94.74%,抗-HBe、抗-HBc 2项同时阳性者阳转率为87.5%。男性抗-HBs阳转率为93.33%,女性为91.67%。结论]接种乙肝疫苗对抗-HBc单项阳性及抗-HBe、抗-HBc 2项同时阳性者,有促进抗-HBs产生的作用。

EXPLORATION OF THE IMMUNE RESPONSE TO HEPATITIS B VACCINE IN PATIENTS WITH POSITIVE ANTI-HBC AND PATIENTS WITH POSITIVE ANTI-HBE AND ANTI-HBC

Objective]To evaluate the immune response to hepatitis B(HB)vaccine in patients with posivive anti-HBc and patients with positive anti-HBe and positive anti-HBc.Methods]Patients with positive anti-HBc and those with positive anti-HBe and positive anti-HBc were inoculated with HB vaccine.One month after the whole inoculation,the anti-HBs level was examined.Results]After HB vaccine inoculation,the total positive conversion rate of anti-HBs was 92.59%.The positive conversion rate of anti-HBs in patients with positive anti-HBc was 94.74%,and that in patients with positive anti-HBe and positive anti-HBc was 87.5%.Besides,the conversion rates of anti-HBs for male and female were 93.33% and 91.67% respectively.Conclusions]The inoculation of HB vaccine can promote the generation of anti-HBs for patients with positive anti-HBc and patients with positive anti-HBe and anti-HBc.