大剂量阿托伐他汀治疗急性脑梗死患者的疗效观察

目的探讨大剂量阿托伐他汀对急性脑梗死患者的治疗效果。方法收集126例急性脑梗死患者,并随机分为治疗组与对照组各63例。对照组仅给予抗血小板聚集、脑保护、清除自由基等常规治疗,治疗组在此基础上,给予阿托伐他汀60mg/d。治疗2周后,比较2组的治疗效果及神经功能缺损评分。结果治疗组治疗后有效率和显效率均显著优于对照组,差异有统计学意义(66.67%vs 44.44%,P<0.05;88.89%vs 63.49%,P<0.01)。治疗后,治疗组的美国国立卫生研究院卒中量表评分低于对照组[(10.1±1.5)分vs(15.5±1.2)分,P<0.01],且未见严重不良反应。结论大剂量阿托伐他汀治疗急性脑梗死疗效显著、安全性较好,值得临床推广。

Therapeutic effect of high-dose atorvastatin on acute ischemic stroke

Objective To study the therapeutic effect of high-dose atorastatin on acute ischemic stroke(AIS).Methods One hundred and twenty-six AIS patients were randomly divided into treatment group and control group(63in each group).The therapeutic effect of high-dose atorastatin and nerve function scores were compared 2weeks after the patients in control group received anti-platelet aggregation,cerebral protection and radical scavenging treatment and those in treatment group underwent anti-platelet aggregation,cerebral protection and radical scavenging treatment plus atorvastatin treatment(60mg/d).Results The effective and very effective rates were significantly higher and the NIHSS score of nerve function was significantly lower in treatment group than in control group(66.67%vs 44.44%,P<0.05,88.89%vs 63.49%,P<0.01;10.1±1.5 vs 15.5±1.2,P<0.01).No severe adverse reacrion occurred in two groups.Conclusion Hgh-dose atorastatin is very effective and safe for AIS with no significant adverse effect,and is thus worthy of popularization in clinical practice.