2342例北京地区儿童血清钙、无机磷水平检测分析

目的研究北京地区儿童血清钙(Ca)、无机磷(P)水平及在儿童生长发育中的变化趋势和影响因素.方法采用分层不等概率二阶整群抽样方法,于2001年9～12月对北京城区和郊区的2 342名10～18岁男女健康儿童进行血清钙(离子电极法)和无机磷(比色法)检测以及膳食状况调查,统计分析血清钙、磷水平与性别、年龄、身高、体重及膳食的关系.结果 (1)北京地区儿童血清钙为(2.39±0.12)mmol/L,与年龄、身高和体重均呈正相关(P＜0.01).总体水平女童略高于男童男:(2.38±0.12)mmol/L,女:(2.39±0.12)mmol/L,P＜0.05];城区儿童明显高于郊区儿童城区:(2.40±0.13)mmol/L,郊区:(2.37±0.10)mmol/L,P＜0.001].(2)北京地区儿童血清无机磷为:(1.39±0.18)mmol/L,与年龄、身高和体重均呈负相关(P＜0.01),男童无机磷显著高于女童男:(1.43±0.18)mmol/L,女:(1.36±0.17)mmol/L,P＜0.001];城区儿童显著高于郊区儿童城区:(1.41±0.19)mmol/L,郊区:(1.38±0.16)mmol/L,P＜0.001].(3)儿童血清钙与无机磷呈负相关(r=-0.141,P＜0.01),Ca]·P]浓度(mmol/L)乘积为3.32±0.44,13～14岁达到峰值3.45±0.46后,随年龄增加而降低.结论北京地区儿童血清钙和无机磷水平随性别、年龄、生长发育和饮食结构等因素变化,健康儿童随年龄增加,血清钙升高,无机磷降低.

Analysis of the levels of serum total calcium and inorganic phosphate of 2,342 children in Beijing

OBJECTIVE: To study the changes of serum total calcium (Ca) and inorganic phosphate (P) levels during children growth and related factors. METHODS: Using a stratified-multi-steps-cluster sampling method, we selected 2,342 healthy children aged 10-18 years from urban and suburban areas of Beijing from September 2001 to December 2001 to test the levels of serum Ca and P. Their meal status was also surveyed to analyse the correlation of the leves of serum Ca and P with sex, age, height, weight, and diet on statistic basis. RESULTS: The Ca levels of Beijing children were (2.39 +/- 0.12) mmol/L, which had a positive correlation with age, height, and weight (P < 0.01). The Ca levels of female children were somewhat higher than those of male male, (2.38 +/- 0.12) mmol/L; female, (2.39 +/- 0.12) mmol/L; P < 0.05]. The Ca levels of urban children were significantly higher than those of suburban children urban, (2.40 +/- 0.13) mmol/L; suburban, (2.37 +/- 0.10) mmol/L; P < 0.001]. The P levels of Beijing children were (1.39 +/- 0.18) mmol/L, which had a negative correlation with age, height, and weight (P < 0.01). The P levels of male children were significantly higher than those of female male, (1.43 +/- 0.18) mmol/L; female, (1.36 +/- 0.17) mmol/L; P < 0.001]. The P levels of urban children were significant higher than those of suburban children urban, (1.41 +/- 0.19) mmol/L; suburban, (1.38 +/- 0.16) mmol/L; P < 0.001]. The Ca levels of Beijing children had a negative correlation with P levels (r=-0.141, P < 0.01). Ca] x P] (mmol/L) of Beijing children were 3.32 +/- 0.44. The value of Ca] x P] reached peak by 3.45 +/- 0.46 when Beijing children were of 13-14 years old, and then the value declined with increasing age. CONCLUSION: The levels of serum Ca and P correlates with sex, age, growth, and diet. The level of serum Ca goes up while P goes down during the children growth.