| 大蒜天然提取物二烯丙基硫醚对亚硝基胍诱发的大鼠腺胃粘损害... |
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| 引用本文： | 胡品津.大蒜天然提取物二烯丙基硫醚对亚硝基胍诱发的大鼠腺胃粘损害...[J].中华肿瘤杂志,1990,12(6):429-431. |
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| 作者姓名： | 胡品津 |
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| 关 键 词： | 二烯丙基硫醚 亚硝基胍 腺胃 大蒜 |
Protective effect of diallyl sulfide, a natural extract of garlic, on MNNG-induced damage of rat glandular stomach mucosa |
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| P J Hu.Protective effect of diallyl sulfide, a natural extract of garlic, on MNNG-induced damage of rat glandular stomach mucosa[J].Chinese Journal of Oncology,1990,12(6):429-431. |
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| Authors: | P J Hu |
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| Institution: | First Hospital, Zhongshan Medical College, Guangzhou. |
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| Abstract: | In order to predict the chemopreventive activity of garlic on gastric cancer, the effect of diallyl sulfide (DAS), a natural extract of the garlic, on MNNG-induced nuclear aberration (NA) and ornithine decarboxylase (ODC) activity in Wistar rat glandular stomach mucosa was studied. The results showed that NA and ODC activity were positively correlated to MNNG dose given 24 and 6 hr after oral intubation with MNNG. Oral or parenteral pretreatment with DAS significantly and dose-dependently inhibited MNNG-induced NA and ODC. These data suggest that DAS has the potential to inhibit MNNG-induced gastric cancer, supporting the epidemiological evidence of the chemopreventive effect of garlic on gastric cancer. |
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