| 荷包牡丹碱对小鼠下丘神经元反应潜伏期的影响 |
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| 引用本文： | 丛文东,肖中举. 荷包牡丹碱对小鼠下丘神经元反应潜伏期的影响[J]. 南方医科大学学报, 2009, 29(5) |
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| 作者姓名： | 丛文东 肖中举 |
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| 作者单位： | 南方医科大学基础医学院生理学教研室,广东,广州,510515 |
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| 摘 要： | 目的 观察荷包牡丹碱对下丘神经元声反应潜伏期改变并分析γ-氨基丁酸(GABA)能神经元在下丘信息处理中的作用.方法 在13只4～5周龄BALB/c小鼠下丘,观察并记录微电泳GABAA受体拮抗剂荷包牡丹碱(bicuculline,methiolide,BMI)对神经元纯频声反应特性的影响.提取特征频率下潜伏期等特性进行分析.结果 共记录到30个单单位神经元,在BMI作用后40%(n=12)的神经元动作电位潜伏期延长,23.3%(n=7)出现特征频率改变,其中潜伏期延长的神经元中有50%(n=6)伴有特征频率改变,阈值改变具有线性趋势.结论 小鼠下丘神经元反应潜伏期形成受GABA能抑制作用,并通过侧抑制作用增高神经元频率选择性.推测潜伏期变化能从突触水平反应GABA能神经元的信息整合作用.
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| 关 键 词： | 下丘神经元 潜伏期 荷包牡丹碱 |
Effect of bicuculline on first spike latency of the neurons in the inferior colliculus of mice |
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| CONG Wen-dong,XIAO Zhong-ju. Effect of bicuculline on first spike latency of the neurons in the inferior colliculus of mice[J]. Journal of Southern Medical University, 2009, 29(5) |
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| Authors: | CONG Wen-dong XIAO Zhong-ju |
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| Affiliation: | CONG Wen-dong,XIAO Zhong-ju Department of Physiology,Southern Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To evaluate the effect of bicuculline on the first spike latency of the neurons in the inferior colliculus of mice and investigate the role of GABA inhibition in sound signal processing of the neurons. Methods In vivo extracellular recording was performed on the inferior colliculus of 13 BALB/c mice (4 to 5 weeks old) to record the neuronal response to pure tones. Bicuculline,a GABA-A receptor antagonist,was applied to the neurons iontophoretically through one channel in the three-barrel glass-pip... |
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| Keywords: | bicuculline first spike latency inferior colliculus |
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