抑郁症中医证候要素辨证量表研究

目的建立抑郁症中医证候要素辨证量表。方法制定抑郁症中医症状条目池调查表,收集434例抑郁症患者的四诊资料,保留出现率≥10%的症状,基于复杂系统嫡聚堆方法提取证候要素。利用向前步进(条件)回归法进行条目筛选,形成条目池;运用二分类Logistic回归分析,确定各症状权重系数,再利用受试者工作特征(ROC)曲线确定各证候要素的诊断阈值。结果经条目筛选最后保留有效条目共39条,在此基础上建立了抑郁症中医证候要素辨证量表。量表中共有气滞、火热、痰湿、气虚、血虚、阴虚、血瘀和阳虚8个证候要素,10分为诊断阈值。结论抑郁症证候要素辨证量表的研制是对抑郁症证候标准化规范化进行的有益探索。

Establishing a TCM pattern element identification scale for depression

Objective To establish a TCM pattern element identification scale for depression.Methods The Questionnaire of TCM Pattern Element Items for Depression was designed.TCM four diagnostic data were collected from 434 cases of depression,and TCM pattern elements of≥10% occurrence fre-quency were retained.TCMpattern elements were extracted based on Complex System Entropy Cluster. Conditional logistic regression of forward method was used for the selection of scale items.Binary logistic regression analysis was used to empower the items.Diagnostic threshold was established by receiver oper-ating characteristic (ROC)curve.Results The TCMpattern element identification scale for depression was established based on 39 valid scale items.There are 8 pattern elements in the scale,including Qi-deficiency,blood-deficiency,Yin-deficiency,Yang-deficiency,Qi-stagnation,fire-heat,phlegm-damp-ness,and blood stasis.The diagnostic threshold score is 10 points.Conclusion Establishing a TCM pattern element identification scale for depression could offer a useful reference for standardization of de-pression patterns.