血清25羟维生素D的测定与糖尿病颈动脉粥样硬化的研究

目的：分析2型糖尿病（T2DM）患者血清25羟维生素 D25（OH）D]水平与颈动脉粥样硬化的关系。方法：选取2型糖尿病患者123名（DM组）其中男74名，女49名。采用化学发光法测定两组受试者血清25（OH）D 水平，用彩色多普勒超声评估颈动脉粥样硬化情况。根据25（OH） D 不同水平将患者分为三组，即维生素 D 缺乏组：25（OH）D ＜20n g／ml（n ＝43）；维生素 D 不足组：20 ng／ml ≤25（OH）D ＜30 ng／ml（n ＝68）；维生素D 充足组：25（OH）D ≥30 ng／ml（n ＝12）。分别检查各组空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇、高密度脂蛋白、低密度脂蛋白。分析各组间各指标的差异及血清25羟维生素 D 与颈动脉粥样硬化的关系。结果：三组患者颈动脉内膜中层厚度差异有统计学意义（P ＜0．05），TG 为颈动脉粥样硬化的独立危险因素，25（OH）D 为颈动脉粥样硬化的独立保护因素，颈动脉内膜中层厚度与25（OH）D 呈显著负相关（P ＜0．05），与 TG 和 HDL －C 呈显著正相关（P 均＜0．05）。结论：25（OH）D 为 T2DM患者颈动脉粥样硬化的独立保护因素。

The relationship between serum 25 hydroxy vitamin D and carotid atherosclerosis in patients with diabetes mellitus

Objective:The relationship between serum 25 hydroxy vitamin D and carotid atherosclerosis in patients with diabetes mellitusMA Jing -xuan1, XU Na1,GUO Shu -qin2,ZHANG Yun -liang2,HUANG Yi -qian2,DU Ya -tao2(1.Chengde Medical University,Chengde 067000;2.The first central hospi-tal of Baoding,Baoding 071000,China)To evaluate the relationship between 25 -hydroxy vitamin D25(OH)D]and carotid artery intimal medial thickness in type 2 diabetes mellitus(T2DM)patients.Methods:Serum 25(OH)D and carotid intimal medial thickness were measured in 123 T2DM patients(male 74,fe-male 49).The level of serum 25(OH)D was detected by using chemiluminescence and carotid artery intimal medial thickness were messured.Patients were divid-ed into three quartile groups according to the serum 25(OH)D levels,group A (25(OH)D <20 ng/mL,n =43),group B(20 ng/ml≤25(OH)D <30 ng/ml,n=68),group C(25(OH)D≥30 ng/ml,n =12).All patients performed the fasting blood glucose,glycosylated hemoglobin(HbA1c),triglyceride(three TG),se-rum total cholesterol(TC),high density lipoprotein cholesterol(HDL -C),low density lipoprotein cholesterol(LDL -C).Results:The three groups were signifi-cantly different in carotid atherosclerosis,and TG was the independent risk factor for carotid atherosclerosis(P <0.05),25(OH)D was the independent protective factor of carotid atherosclerosis(P <0.05).Carotid artery intimal medial thickness was negative related to 25(OH)D(P <0.05),was positively correlated with TG and.