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EFFICACY OF ORALLY ADMINISTERED ONDANSETRON IN THE PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING: A DOSE RANGING STUDY |
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| Authors: | KENNY G N C; OATES J D L; LEESER J; ROWBOTHAM D J; LIP H; RUST M; SAUR P; ONSRUD M; HAIGH C G |
| Institution: | 1Department of Anaesthesia, University of Glasgow Glasgow G31 2ER 2Department of Anaesthesia, Royal Liverpool University Hospital Liverpool L7 8XP 3Department of Anaesthesia, Onze Lieve Vrouwe Gasthuis 1091 HA Amsterdam, The Netherlands 4University Department of Anaesthesia, Leicester Royal Infirmary Leicester LEI 5WW 5Department of Anaesthesia, Sophia Ziekenhuis 8000 GK Zwolle, Trie Netherlands 6Institut fur Anasthes-iologie, Technische Universitfit Munchen 8 Munchen 80, Germany 7Anaesthesiologie, Universitatsklinik Gottingen 3400 G6ttingen, Germany 8Department of Gynaecology, University Hospital 7006 Trondheim, Norway 9Gastrointestinal New Chemical Entities Department, Glaxo Group Research Limited Green-ford, Middlesex UB6 0HE |
| Abstract: | In a placebo-controlled, double-blind study, we have comparedthe efficacy of ondansetron 16 mg, 8 mg and 1 mg administered8-hourly for prevention of postoperative nausea and vomiting.We studied 995 patients undergoing major gynaecological surgery;982 were included in the analysis. Study medication was administered1 h before induction of anaesthesia and second and third doseswere given 8 and 16 h after the first. The treatment groupswere similar for patient characteristics, surgical procedures,anaesthetics administered and opioids given. The frequency ofnausea was 75%, 70%, 56% and 55% after placebo and ondansetron1 mg, 8 mg and 16 mg, respectively; the corrresponding frequenciesof vomiting were 60%, 55%, 37% and 37%. Ondansetron 8 mg wasas effective as 16 mg and both resulted in significant reductionsin nausea and vomiting compared with placebo and ondansetron1 mg (P < 0.001). |
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