| 血管内皮细胞生长因子抗体对胶质瘤生长的影响 |
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| 引用本文： | 曲元明,韩韬,李桂林,王成伟. 血管内皮细胞生长因子抗体对胶质瘤生长的影响[J]. 山东大学学报(医学版), 2001, 39(2): 138-140 |
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| 作者姓名： | 曲元明 韩韬 李桂林 王成伟 |
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| 作者单位： | 山东省立医院神经外科 |
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| 基金项目： | 山东省卫生厅资助课题(9704) |
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| 摘 要： | 探讨血管内皮细胞生长因子(vascularendothelialgrowthfctor，VEGF)对胶质瘤生长的抑制作用。方法应用vEGF抗体作用于C6胶质瘤细胞动物肿瘤模型，观察其抑瘤作用；应用SABC免疫组化技术检测体内生长胶质瘤中微血管密度。结果VEGF抗体对体内生长的胶质瘤有显著抑制作用且呈剂量依赖关系，押瘤率可达82.8％(P<0.01)。经VEGF抗体治疗的胶质瘤中微血管密度较对照组降低(P<0.01)。结论vEGF抗体通过抑制血管生成而抑制胶质瘤生长。
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| 关 键 词： | 内皮细胞生长因子；胶质瘤；微血管密度；免疫组织化学 |
| 文章编号： | 1000-0496(2001)02-0138-03 |
| 修稿时间： | 2000-06-02 |
THE EFFECT OF ANTI-VEGFANTIBODY ON GLIOMA GROWTH |
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| QU Yuan ming,HAN Tao,LI Gui lin,et al. THE EFFECT OF ANTI-VEGFANTIBODY ON GLIOMA GROWTH[J]. Journal of Shandong University:Health Sciences, 2001, 39(2): 138-140 |
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| Authors: | QU Yuan ming HAN Tao LI Gui lin et al |
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| Abstract: | Objective:To explore the inhibitory role of anti VEGF antibody on glioma growth.Methods:Anti VEGF antibody was used to treat the tumor models of C6 glioma cell lines.The tumor inhibition rate was calculated and the glioma microvessel density was detected by SABC immunohistochemical techniques.Results:The anti VEGF antibody inhibited the growth of the glioma remarkbly in a dose dependent manner.The tumor inhibition rate was 82.8%(P<0.01).Micrangium density of the glioma treated by anti VEGF antibody was lower than that of the control group(P<0.01).Conclusion:Anti VEGF antibody can inhibit the glioma growth by inhibitting angiogenesis. |
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| Keywords: | Endothelial growth factor Glioma Microvessel density Immunohistochemistry |
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