| 凹脉丁公藤化学成分的研究 |
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| 引用本文： | 陆阳,姚天荣,陈泽乃. 凹脉丁公藤化学成分的研究[J]. 药学学报, 1986, 21(11): 829-835 |
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| 作者姓名： | 陆阳 姚天荣 陈泽乃 |
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| 作者单位： | 上海第二医科大学化学教研室,*八二级天然药物化学专业硕士研究生 |
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| 摘 要： | 自凹脉丁公藤(Erycibe elllptilimba Merr.et Chun)中分得两个香豆素和三个生物碱。经鉴定分别为东莨菪素(scopoletin Ⅰ),东莨菪甙(scopolin Ⅱ),包公藤甲素(Ⅲ),包公藤丙素(Ⅳ)和一新的水溶性生物碱,结构为2β,7β-二羟基去甲茛菪烷,命名为凹脉丁公藤碱(erycibelline,Ⅴ)。包公藤丙素(Ⅳ)是首次分离得到纯品,其O-二乙酰化物(Ⅳa)具有缩瞳活性。
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| 关 键 词： | 凹脉丁公藤 莨菪烷生物碱 包公藤丙素 凹脉丁公藤碱 缩瞳剂 |
| 收稿时间： | 1985-10-23 |
STUDIES ON THE CONSTITUENTS OFERYCIBE ELLIPTLLIMBA |
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| LU Yang,YAO Tian-Rong and CHEN Ze-Nai. STUDIES ON THE CONSTITUENTS OFERYCIBE ELLIPTLLIMBA[J]. Acta pharmaceutica Sinica, 1986, 21(11): 829-835 |
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| Authors: | LU Yang YAO Tian-Rong CHEN Ze-Nai |
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| Abstract: | Five compounds have been isolated from the stem of Erycibe elliptilimba Merr. et Chun. By spectral analyses and chemical reactions four of them have been identified as scopoletin(Ⅰ), scopolin(Ⅱ), Bao-Gong-Teng A(Ⅲ),and Bao-Gong-Teng C(Ⅳ). (Ⅰ) and (Ⅱ) can be used as antirheumatic and analgesic; while (Ⅲ) can be used as myotic. The fifth one, 2β, 7β-dihydroxynortropane, is a new alkaloid named erycibelline(Ⅴ). Forthe first time (Ⅳ)is obtained as a pure colorless oil. It has been found that although (Ⅳ) Showed no obvious biologic activity, its O-diacetyl derivative (Ⅳa) is a strong myotic. |
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| Keywords: | Tropane alkaloid . Bao-Gong-Teng C Erycibelline Myotic Erycibe elliptilimba Merr. et Chun |
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