血清胃泌素水平与冠心病相关性研究

目的 研究血清胃泌素(gastrin)水平与冠心病(coronary heart disease,CHD)之间的关系.方法 采用病例对照研究方法,收集2013-2014年在我科住院的冠心病患者83例资料,冠心病的诊断根据冠脉造影所显示的结果,根据病变涉及的冠脉支数将其分为单支、2支、3支病变组,按照Gensini积分计算冠心病组人群的冠脉病变严重程度.以年龄、性别、是否有消化道疾病与冠心病组进行1∶1匹配,无冠心病且无重要脏器疾病为对照组.应用酶联免疫吸附法测定入选人群的空腹血清胃泌素水平(fasting serum gastrin,FG)及标准餐后1h血清胃泌素(PG1h)水平.结果 冠心病组较对照组PG1h及PG1 h/FG显著升高(P ＜0.01);Logistic回归模型控制冠心病的危险因素后发现PG1 h/FG是冠心病的危险因素;同时,在冠心病组中发现,PG1h/FG与冠脉病变严重程度的指标Gensini积分具有相关性,且成正相关(r2=0.453).结论 餐后1h血清胃泌素水平升高与冠心病相关,餐后1h血清胃泌素/空腹胃泌素与冠心病病变严重程度呈正相关.

Correlation between coronary heart disease and serum gastrin level

Objective To investigate the correlation between serum gastrin level and coronary heart disease (CHD).Methods A case-control method was used in this research.Eighty-three patients were selected as the CHD group according to the results of coronary angiography in our department from January 2013 to December 2014.The CHD group was divided into single-branch lesion group,double-branch lesion group and triple-branch lesion group according to the results of coronary angiography.The lesion severity of CHD was calculated with Gensini scores.Participants of the control group had no CHD and other diseases of important organs.The age,gender and digestive tract disease of the control group were matched with those of the CHD group.Enzyme-linked immunosorbent assay was used to measure the levels of fasting serum gastrin (FG) and postprandial 1 h serum gastrin (PG1h).Results PG1h and PG1h/FG in the CHD group significantly increased compared with the control group (P ＜0.01).It showed that PG1h/FG was a risk factor of CHD after controlling the confounding factors of CHD with Logistic regression model.PG1h/FG was positively correlated with the lesion severity of CHD in the CHD group (r2 =0.453).Conclusion The increase of serum gastrin level is not only correlated with CHD,but also positively correlated with the lesion severity of CHD.