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The Plasticity of γδ T Cells: Innate Immunity,Antigen Presentation and New Immunotherapy
引用本文:Casetti R,Martino A. The Plasticity of γδ T Cells: Innate Immunity,Antigen Presentation and New Immunotherapy[J]. Cellular & molecular immunology, 2008, 5(3): 161-170
作者姓名:Casetti R  Martino A
作者单位:[1]Unit of Cellular Immunology "Fabrizio Poccia", National Institute for Infectious Diseases-IRCCS, Lazzaro Spallanzani, Via Portuense 292, 00149 Rome, Italy; [2]Unit of Cellular Immunology "Fabrizio Poccia", National Institute for Infectious Diseases-IRCCS, Lazzaro Spallanzani, Via Portuense 292, 00149 Rome
摘    要:Several signals influence dendritic cell (DC) functions and consequent the immune responses to infectious pathogens. Our recent findings provide a new model of intervention on DCs implicating human γδ T cell stimuli. Vγ/9Vδ2 T cells represent the major subset of circulating human γδ T cells and can be activated by non-peptidic molecules derived from different microorganisms or abnormal metabolic routes. With activated-Vγ/9Vδ2 T cell co-culture, immature DCs acquire features of mature DCs, such as increasing the migratory activity, up-regulating the chemokine receptors, and triggering the Thl immune response. Similar to the NK-derived signals, DC activation is mediated by soluble factors as well as cell-to-cell contact. Many non-peptidic molecules including nitrogen- containing bisphosphonates and pyrophosphomonoester drugs, can stimulate the activity of Vγ/9Vδ2 T cells in vitro and in vivo. The relatively low in vivo toxicity of many of these drugs makes possible novel vaccine and immune-based strategies against infectious diseases.

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The plasticity of gamma delta T cells: innate immunity, antigen presentation and new immunotherapy
Casetti Rita,Martino Angelo. The plasticity of gamma delta T cells: innate immunity, antigen presentation and new immunotherapy[J]. Cellular & molecular immunology, 2008, 5(3): 161-170
Authors:Casetti Rita  Martino Angelo
Affiliation:Unit of Cellular Immunology Fabrizio Poccia, National Institute for Infectious Diseases-IRCCS, Lazzaro Spallanzani, Rome, Italy.
Abstract:Several signals influence dendritic cell (DC) functions and consequent the immune responses to infectious pathogens. Our recent findings provide a new model of intervention on DCs implicating human gammadelta T cell stimuli. Vgamma9Vdelta2 T cells represent the major subset of circulating human gammadelta T cells and can be activated by non-peptidic molecules derived from different microorganisms or abnormal metabolic routes. With activated-Vgamma9Vdelta2 T cell co-culture, immature DCs acquire features of mature DCs, such as increasing the migratory activity, up-regulating the chemokine receptors, and triggering the Th1 immune response. Similar to the NK-derived signals, DC activation is mediated by soluble factors as well as cell-to-cell contact. Many non-peptidic molecules including nitrogen-containing bisphosphonates and pyrophosphomonoester drugs, can stimulate the activity of Vgamma9Vdelta2 T cells in vitro and in vivo. The relatively low in vivo toxicity of many of these drugs makes possible novel vaccine and immune-based strategies against infectious diseases.
Keywords:T cell   dendritic cell   innate immunity   immunotherapy
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