Effect on high-density lipoprotein cholesterol of maximum dose simvastatin and atorvastatin in patients with hypercholesterolemia: results of the Comparative HDL Efficacy and Safety Study (CHESS) |
| |
Authors: | Ballantyne Christie M Blazing Michael A Hunninghake Donald B Davidson Michael H Yuan Zhong DeLucca Paul Ramsey Karen E Hustad Carolyn M Palmisano Joanne |
| |
Institution: | a Baylor College of Medicine, Houston, Tex, USA b Duke University Medical Center, Durham, NC, USA c Heart Disease Prevention Clinic, Minneapolis, Minn, USA d Chicago Center for Clinical Research, Chicago, Ill, USA e Merck & Co, Inc, West Point, Pa, USA |
| |
Abstract: | BackgroundPrevious studies have shown that effects on high-density lipoprotein cholesterol (HDL-C) may differ among statins.MethodsA multicenter, randomized, double-blind, parallel-dose study was conducted in 917 hypercholesterolemic patients to compare the efficacy of 80 mg/d simvastatin versus 80 mg/d atorvastatin on HDL-C and apolipoprotein (apo) A-I for 24 weeks. Efficacy was assessed as the means of weeks 6 and 12 and weeks 18 and 24. Prespecified subgroups analyzed were patients with low HDL-C levels and with the metabolic syndrome.ResultsSimvastatin increased HDL-C and apo A-I values significantly more than did atorvastatin for the mean of weeks 6 and 12 (8.9% vs 3.6% and 4.9% vs −0.9%, respectively) and the mean of weeks 18 and 24 (8.3% vs 4.2% and 3.7% vs −1.4%). These differences were observed across both baseline HDL-C subgroups (<40 mg/dL, ≥40 mg/dL) and in patients with the metabolic syndrome. Low-density lipoprotein cholesterol and triglyceride reductions were greater with atorvastatin. Consecutive elevations >3× the upper limit of normal in alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) occurred in significantly fewer patients treated with simvastatin than with atorvastatin (2/453 0.4%] vs 13/464 2.8%]), with most elevations observed in women taking atorvastatin (11/209 5.3%] vs 1/199 0.5%] for simvastatin).ConclusionsSimvastatin (80 mg) increased HDL-C and apo A-I significantly more than did atorvastatin (80 mg) in patients with hypercholesterolemia. This advantage was observed regardless of HDL-C level at baseline or the presence of the metabolic syndrome. Significantly fewer consecutive elevations >3× the upper limit of normal in ALT and/or AST occurred in patients receiving simvastatin. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|