Therapieoptionen der perioperativ erworbenen Thrombozytopathie |
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Authors: | Dr CF Weber AC Schneider T Kirschning C Hofstetter K Zacharowski K Görlinger |
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Institution: | 1. Klinik für An?sthesiologie, Intensivmedizin und Schmerztherapie, Klinikum der Johann Wolfgang Goethe-Universit?t Frankfurt am Main, Theodor-Stern-Kai 7, 60590, Frankfurt, Deutschland 3. Klinik für Anaesthesiologie und Operative Intensivmedizin, Universit?tsmedizin Mannheim, Mannheim, Deutschland 2. Klinik für An?sthesiologie und Intensivmedizin, Universit?tsklinikum Essen, Universit?t Duisburg-Essen, Essen, Deutschland
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Abstract: | Increased intra-operative and postoperative blood loss might be caused by acquired platelet function disorders. In particular because conventional coagulation analyses and platelet count fail to detect impaired platelet function, implementation of bedside-tests for platelet function in the peri-operative period is desirable according to the results of retrospective studies. Following adequate adjustment of basic conditions of haemostasis (e.g. temperature, pH, Ca2+-concentration, haematocrit) a pharmacological approach with desmopressin (1-desamino-8-d-arginine vasopressin; DDAVP) or tranexamic acid potentially represents a low cost alternative to platelet transfusions with minor side effects. |
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