熊去氧胆酸治疗妊娠肝内胆汁淤积症17例

目的：评价熊去氧胆酸(UDCA)治疗妊娠期肝内胆汁淤积症(ICP)的效果。方法：38例患者，随机分成两组。治疗组17例，采用UDCA 100 mg，po，tid。对照组21例，给予10%葡萄糖注射液500 mL，维生素C 3 g，肌苷0.4 g，静脉滴注，两组均以14 d为1个疗程，观察疗效。结果：治疗组瘙痒评分治疗1周后明显下降，血丙氨酸氨基转移酶(ALT)和血清总胆汁酸(TBA)明显下降(P＜0.05)，而对照组无明显改变(P＞0.05)；与对照组相比，治疗组早产、胎儿窒息、羊水粪染发生明显减少(P＜0.05)。结论：UDCA是治疗ICP安全、有效的药物。

Treatment of Seventeen Intraheptic Cholestasis Patients during Pregnancy by Ursodeoxycholic Acid

Objective:To observe the effect of ursodeoxycholic acid (UDCA) in treatment of intraheptic cholestasis patients during pregnancy. Methods:Thirty-eight suitable patients were randomised into two groups. The treatment group(n=17) took UDCA 100 mg, po, tid; the control group(n=21) received 10% glucose injection with VitC and inosine, iv, gtt. Both group were observed for 14 d. Results:One week later, itching scores, and plasma ALT and TBA, as well as occurrences of fetal distress, preterm labour and meconium staining in amniotic fluid in the treatment group were lowered significantly than in the control group (P<0.05). Conclusion:UDCA is a safe, effective drug in the treatment of intraheptic cholestasis patients during pregnancy.