Glutamate-induced disturbances in neurotransmission and ionic homeostasis of extracellular Ca2+ and K+ in CA1 hippocampal area |
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| Authors: | V. G. Motin |
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| Affiliation: | (1) P. K. Anokhin institute of Nornal Physiology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | The effect of various concentrations ofl-glutamate on neurotransmission in the CA1 hippocampal area was studied using hippocampal slices. Three intervals ofl-glutamate concentration were established: ≤1 mM (all studied parameters are completely reversible upon washout, transmission being preserved), from 1 to 10 mM (both responses to frequency stimulation and single population spikes remain partially suppressed after washout), and above 10 mM (more than 50% suppression of transmission persists after washout). Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 9, pp. 255–258, September, 1997 |
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| Keywords: | hippocampus calcium potassium CA1 ion-selective electrodes |
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