The role of the cerebral cortex and subcortical centers in the regulation of blood cholesterol levels

Summary Development of a conditioned reflex to inhibition of respiration in the rabbit is accompanied by a decline of blood cholesterol. Feeding cholesterol to animals in a state of conditioned reflex activity did not result in hypercholesterinemia, while in control animals cholesterol feeding caused a rise of blood serum cholesterol. The cerebral cortex and subcortical formations are thus participating in the regulation of cholesterol metabolism.Preliminary data demonstrating deposition of lipoids in vascular walls of experimental rabbits, point to the possibility of vascular lipoidosis being caused by altered nervous regulation, the cholesterol blood level being normal.Presented by Active Member of the Academy of Medical Sciences USSR Professor P. S. Kupalov